Tropical Spastic Paraparesis

A subacute paralytic myeloneuropathy occurring endemically in tropical areas such as the Caribbean, Colombia, India, and Africa, as well as in the southwestern region of Japan; associated with infection by HUMAN T-CELL LEUKEMIA VIRUS I. Clinical manifestations include a slowly progressive spastic weakness of the legs, increased reflexes, Babinski signs, incontinence, and loss of vibratory and position sensation. On pathologic examination inflammatory, demyelination, and necrotic lesions may be found in the spinal cord. (Adams et al., Principles of Neurology, 6th ed, p1239)

Also Known As:

Tropical Spastic Paraplegia; Paraparesis, Tropical Spastic; Familial Spastic Paraparesis, Htlv-1-Associated; HTLV I Associated Myelopathies; HTLV-I-Associated Myelopathy-Tropical Spastic Paraparesis; Human T-Lymphotropic Virus Type 1 Associated Myelopathy; Myelopathies, HTLV I Associated; Myelopathy, Htlv-1-Associated; Myelopathy, Human T-Lymphotropic Virus Type 1 Associated; Paraplegia, Tropical Spastic; Familial Spastic Paraparesis, Htlv 1 Associated; HTLV I Associated Myelopathy; HTLV I Associated Myelopathy Tropical Spastic Paraparesis; HTLV-I-Associated Myelopathies; Htlv-1-Associated Myelopathies; Htlv-1-Associated Myelopathy; Human T Lymphotropic Virus Type 1 Associated Myelopathy; Myelopathies, HTLV-I-Associated; Myelopathies, Htlv-1-Associated; Myelopathy, HTLV-I-Associated; Myelopathy, Htlv 1 Associated; Myelopathy, Human T Lymphotropic Virus Type 1 Associated; Parapareses, Tropical Spastic; Paraplegias, Tropical Spastic; Spastic Parapareses, Tropical; Spastic Paraparesis, Tropical; Spastic Paraplegia, Tropical; Spastic Paraplegias, Tropical; Tropical Spastic Parapareses; Tropical Spastic Paraplegias; HTLV-I-Associated Myelopathy

Infections: 539155
- Virus Diseases: 42919
  - RNA Virus Infections: 309
    - Retroviridae Infections: 334
      - Deltaretrovirus Infections: 258
        HTLV-I Infections: 328
        Tropical Spastic Paraparesis: 495
- Central Nervous System Infections: 1428
  - Myelitis: 892
    - Tropical Spastic Paraparesis: 495
Nervous System Diseases: 14737
- Neuroinflammatory Diseases: 19509
  - Myelitis: 892
    - Tropical Spastic Paraparesis: 495
- Central Nervous System Diseases: 4371
  - Spinal Cord Diseases: 4420
    - Myelitis: 892
      - Tropical Spastic Paraparesis: 495
  - Central Nervous System Infections: 1428
    - Myelitis: 892
      - Tropical Spastic Paraparesis: 495

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